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Antibody-points Bulletin: MOG
Be on the lookout for: MOG. MOG is a primary target antigen involved in immune-mediated demyelination; has been found to be effective in combating muscular dystrophy. ..
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Antibody-points Bulletin: ISG15
Be on the lookout for: ISG15. Be on the lookout for: ISG15. Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protei..
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Understanding How HIV Beats Early Immune Response
In an important step towards eradicating HIV-associated viral reservoirs, researchers have identified how the HIV virus hijacks the innate immune system to facilitate its replication and spread, thus ..
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Antibody-points Bulletin: PPIA
Be on the lookout for: PPIA. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. PPIA is believed to inhibit HIV-1 inf..
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Mechanism of CypA Inhibition of HIV-1 Infection
Vanderbilt researchers find that CypA inhibits HIV-1 infection by blocking nuclear import of the HIV-1 preintegration complex. ..
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Antibody-points Bulletin: Tumor Protein 53
Be on the lookout for: Tumor Protein 53. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. TP53 is frequently m..
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Antibody-points Bulletin: CD40 ligand
Be on the lookout for CD40LG: CD40 ligand. CD40 ligand regulates B cell function by engaging CD40 on the B cell surface. In early HIV infection, CD40L expression contributes to the immunological contr..
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Novel Approach Offers New Insights Into HIV’s Lifecycle
Live-cell fluorescent imaging system identifies individual viral particles associated with infection. .smallWindo..
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Antibody-points Bulletin: ADIPOR2
Be on the lookout for ADIPOR2: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal revascularization after c..
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Discovery of Potential Broad-Spectrum Antiviral Targeting EZH2/1 Complex
The spread of herpes simplex virus infection is suppressed in cells treated with EZH2/1 inhibitors (GSK126 or GSK343). ..
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Antibody-points Bulletin: RAB7A
Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in..
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Protein Critical to Early Stages of Cellular HIV Infection Identified
Tokyo Medical and Dental University (TMDU)-led researchers identify a protein critical to the early stages of infection of cells by HIV, offering a potential target for anti-HIV treatment. ..
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Antibody-points Bulletin: PECAM1
Be on the lookout for PECAM1: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell..
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Creating Resistance to HIV Via CRISPR
Mice transplanted with human hematopoietic stem cells that have an HIV receptor gene, CCR5, disrupted by gene editing allows the animals to ward off HIV infection. ..
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Kitchen Sponges Are Bacterial Paradise
Study shows that your kitchen sponge is a germ-ridden and nasty. ..
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Antibody-points Bulletin: AFAP1
Be on the lookout for AFAP1: The protein encoded by this gene is a Src binding partner. Antibody-points Bulletin: AFAP1 .largeWrapper { backgr..
Read moreAntibody-points Bulletin: Noggin
Be on the lookout for Noggin: Noggin is suspected of inhibiting BMPs and being a cause of symphalangism. Antibody-po..
Read moreAntibody-points Bulletin: GSK3A
GSK3A encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also pla..
Read moreAntibody-points Bulletin: Mucin-20
Mucin-20 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family ..
Read moreUse of REV-dependent HIV reporter cell, REV-CEM-GFP/Luc, helps lead to discovering small molecular inhibitors that block the HIV host dependency factor LIMK1
The actin cytoskeleton plays an important role in HIV entry, intracellular migration, and viron release. LIM domain kinase (LIMK) regulates actin cytoskeleton by phosphorylating cofilin. HIV can gain..
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