Antibody-points Bulletin: PECAM1

Antibody-points Bulletin: PECAM1
Aug-07-2017 0 comments Cube Biosystems

Antibody-points Bulletin: PECAM1

BOLO:

Name: Platelet/Endothelial Cell Adhesion Molecule 1

PECAM1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.
Artist Rendering of PECAM1 (AA:28-232)
Source: Swiss-Model  
CC License

PID: P16284

GID: 5165

Nicknames: PECAM 1

AKA: CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM0

Vitals:

   Origins: 17a23.3
   DNA: 94430 bp, NC_000017 (64319415..64413844)
   RNA: 6831 bp
   Exons: 19
   Protein: 738 aa, 82.5 kDa

Description:

Be on the lookout for AFAP1: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.

Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and spreading on fibronectin.

Protein of Interest in the Following Cases:

PECAM1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.

Source: Open Targets Platform

Last Known Addresses:

  •  Cell Membrane
  •  Cell Junction

Known Hangouts:

PECAM1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.

Source: NCBI

Known Associates:

PECAM1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.

Source: BioGrid

Gang Associations:

  •  Cell Ahdesion
  •  Cell Recognition
  •  Diapediesis
  •  Extracellular Matrix Organization
  •  Glomerular Endothelium
  •  Leukocyte Migration
  •  Phagocytosis
  •  Signal Transduction

Known Weaknesses: None

Reported Sightings:

PECAM1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions.

Source: Pubmed

Means of Capture:

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