Overview
Properties
Sensitivity: | < 50 pg/ml |
Storage Instructions: | Store at 4˚C for 1 month, at -20˚C for up to longer storage. Avoid multiple freeze/thaw cycles (Shipped with blue ice.) |
Kit Components
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Material Required But Not Provided
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Background
Gene Name: | Aggrecan |
Background: | Aggrecan, also known as cartilage - specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. It is a critical component for cartilage structure and the function of joints. Aggrecan provides intervertebral disc and cartilage with the ability to resist compressive loads. The localized high concentrations of aggrecan provide the osmotic properties necessary for normal tissue function with the GAGs producing the swelling pressure that counters compressive loads on the tissue. This functional ability is dependent on a high GAG/aggrecan concentration being present in the tissue extracellular matrix. Also, Aggrecan plays an important role in the organization of the extracellular spaces between neurons in the brain. |
Synonym: | ACAN; AGC 1; AGC1; AGCAN; Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122); Aggrecan 1; Aggrecan core protein; Aggrecan proteoglycan; Aggrecan structural proteoglycan of cartilage; Aggrecan1; ATEGQV; Cartilage specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122; Chondroitin sulfate proteoglycan core protein 1; CS pg 1; CS pg1; CS pgCP; JSCATE; Large aggregating proteoglycan; mcs pg; mgsk16; MSK 16; MSK16; SEDK |
NCBI Gene ID: | 176 |
UniProt ID: | P16112 |
Intra/Inter Assay Precision
Intra | Inter | |||||
Sample: | 1 | 2 | 3 | 1 | 2 | 3 |
n: | 16 | 16 | 16 | 24 | 24 | 24 |
Mean (ng/ml): | 15 | 42 | 74 | 16 | 41 | 72 |
Standard deviation: | 0.825 | 1.806 | 4.588 | 0.944 | 2.255 | 4.824 |
CV (%): | 5.5 | 4.3 | 6.2 | 5.9 | 5.5 | 6.7 |
Typical Data
Concentration (ng/ml): | 0 | 1.56 | 3.12 | 6.25 | 12.5 | 25 | 50 | 100 |
O.D.: | 0.004 | 0.069 | 0.175 | 0.333 | 0.559 | 1.021 | 1.672 | 2.054 |
Review