Antibody-points Bulletin: Mucin-20
Antibody-points Bulletin: Mucin-20
Name: Mucin-20
PID: Q8N307
GID: 200958
Nicknames: MUC-20, Muc20
AKA: KIAA1359
Description:
Be on the lookout for Mucin-20. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Last Known Addresses:
• Apical cell membrane
• Basolateral cell membrane
• Microvillus membrane
Known Hangouts:
Source: NCBI
Gang Associations:
• O-Glycan Processing
• Activation Of Mapk Activity
• Hepatocyte Growth Factor Receptor Signaling Pathway
• Protein Homooligomerization
• Stimulatory C-Type Lectin Receptor Signaling Pathway
Known Weaknesses: Not yet determined
Means of Capture:
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