Antibody-points Bulletin: PPIA
Antibody-points Bulletin:
Peptidyl-prolyl cis-trans isomerase A
BOLO:
Name: Peptidyl-prolyl cis-trans isomerase A
PID: P62937
GID: 5478
Nicknames: PPIA
AKA: CYPA, CYPH, HEL-S-69p, PPIase A, Cyclophilin A, Rotamase A
Vitals:
Origins: 17p13.1
DNA: NC_000007.14 6488 bp, (44796636..44803123)
RNA: NM_001300981.1 2455 bp
Exons: 6
Protein: 165 aa, 18 kDa
Description:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
PPIA is believed to inhibit HIV-1 infection by blocking nuclear import of the HIV-1 preintegration complex.
Gang Associations:
•
• Establishment Of Integrated Proviral Latency
• Fusion Of Virus Membrane With Host Plasma Membrane
• Leukocyte Migration
• Lipid Particle Organization
• Neuron Differentiation
• Neutrophil Degranulation
• Positive Regulation Of Protein Secretion
• Positive Regulation Of Viral Genome Replication
• Protein Folding
• Protein Peptidyl-Prolyl Isomerization
• Regulation Of Viral Genome Replication
• Rna-Dependent Dna Biosynthetic Process
• Uncoating Of Virus
• Viral Life Cycle
• Viral Release From Host Cell
• Virion Assembly
Known Weaknesses:
Cyclosporine for
• Chronic Obstructive Pulmonary Disease
• Acute Graft vs. Host Disease
• Acute Kidney Injury
• Allergic Conjunctivitis
• Atopic Eczema
• Bronchiolitis Obliterans
• Chronic Interstitial Cystitis
• Chronic Kidney Disease
• Focal Segmental Glomerulosclerosis
• Glaucoma
• Leprosy
• Psoriasis
• Abdominal Aortic Aneurysm
• Acute Myeloid Leukemia
• Autoimmune Hepatitis
• Dry Eye Syndrome
• Chronic
• Diabetes Mellitus
• Lymphoid Leukemia
• Lymphoma
• Autoimmune Thrombocytopenic Purpura
Means of Capture:
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