Antibody-points Bulletin: ADIPOR2

BOLO:

Name: Adiponectin Receptor 2

PID: Q86V24

GID: 79602

Nicknames: ADIPOR2

AKA: PAQR2, ACDCR2

Vitals:

   Origins: 12p13.33
   DNA: 97699 bp, NC_000012 (1690981..1788679)
   RNA: 3982 bp
   Exons: 9
   Protein: 386 aa, 43.8 kDa

Description:

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels.

Protein of Interest in the Following Cases:

Source: Open Targets Platform

Last Known Addresses:

  •  Cell Membrane

Known Hangouts:

Most likely to be found in Adipose tissue, Adrenal Gland, Cerebral Cortex, Thyroid Gland and Liver.

Source: Human Protein Atlas

Known Associates:

Source: BioGrid

Gang Associations:

  •  Fatty Acid Oxidation
  •  Female Pregnancy
  •  Glucose Homeostasis
  •  Heart Development
  •  Hormone-Mediated Signaling Pathway
  •  Negative Regulation Of Cell Growth
  •  Positive Regulation Of Glucose Import
  •  Regulation Of Fatty Acid Biosynthetic Process
  •  Response To Nutrient
  •  Vascular Wound Healing

Known Weaknesses: None

Reported Sightings:

Source: Pubmed

Means of Capture: