Top Trending Gene Targets for Antibodies

Top Trending Gene Targets for Antibodies
Sep-14-2015 0 comments Cube Biosystems

Now that whole genome sequence is known, it is interesting to see what genes have captured the research community's attention.  As part of our interest in tracking the most widely studied genes, we wanted to look at the growth and trends of the use of antibodies against some of the more widely known genes.  Utilizing the 2005-2010 period as a baseline, we charted the publication numbers associated with antibodies and their gene targets. Table 1 contains a list of some of the top trending, widely known genes  -- as it relates to antibody targets.  The most positive trending gene by publication growth rate is VEGF-A (more than doubling its publication numbers over the previous five year period); while, as noted in a previous post, CD40L is the most studied gene utilizing antibodies, among this group.   



Top Trending Genes Targeted by Antibodies

Top Trending Genes Being Studied Utilizing Antibodies

Rank Gene Symbol Gene Name Function
1 VEGFA Vascular Endothelial Growth Factor A Cardiovascular, Cancer, Immunology, Neuroscience
2 PECAM1 Platelet/Endothelial Cell Adhesion Molecule 1 Extracellular Matrix, Cell Migration
3 EGFR/ERBB Epidermal Growth Factor Cancer
4 CD79A CD79a Molecule, Immunoglobulin-Associated Alpha Immunology
5 MBOAT1/LPLAT Membrane Bound O-Acyltransferase Domain Containing 1 Neuroscience
6 CD40L CD40 Ligand Immunology
7 NLRC4 NLR Family, CARD Domain Containing 4 Immunology, Inflammation, Apoptosis
8 HSD3B1 Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1 Endocrinology, hormone
9 LMNA Lamin A/C Cytoskeleton
10 IL36RN Interleukin 36 Receptor Antagonist Immunology
11 TCN2 Transcobalamin II Vitamin Absorption
12 VIPR1 Vasoactive Intestinal Peptide Receptor 1 Neuroscience, Signalling
13 TAF8 TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor Transcription Regulation
14 GCNT2 Glucosaminyl (N-Acetyl) Transferase 2, I-Branching Enzyme (I Blood Group) Glycosylation
15 CD74 CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain Immunology
16 ELF2 E74-Like Factor 2 Transcription Regulation
17 SERPINH1 Serpin Peptidase Inhibitor, Clade H (Heat Shock Protein 47), Member 1, (Collagen Binding Protein 1) Intracellular Signalling
18 CSF2RA Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) Cell Proliferation, Immunology
19 RLN3/H3 Relaxin Endocrine and Autocrine/paracrine Systems
20 HIST2H3C Histone Cluster 2, H3c Chromatin
21 MBOAT4 4-Membrane Bound O-Acyltransferase Domain Containing 1 Glycosylation
22 CACNA1F Calcium Channel, Voltage-Dependent, L Type, Alpha 1F Subunit Ion Channels, Neuroscience
23 MYC V-Myc Avian Myelocytomatosis Viral Oncogene Homolog Cancer
24 GSTK1 Glutathione S-transferase kappa 1 Cell Detoxicfication
25 SLCO6A1 Solute Carrier Organic Anion Transporter Family, Member 6A1 Ion Transporter



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