Antibody-points Bulletin: MOG
Name: Myelin-oligodendrocyte glycoprotein
AKA: BTN6, BTNL11, MOGIG2, NRCLP7
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.By similarity (Microbial infection) Acts as a receptor for rubella virus.
Protein of Interest in the Following Cases:
Source: Open Targets Platform
Last Known Addresses:
• Cell adhesion
• Central nervous system development
• Host-virus interaction
Known Weaknesses: Unknown
Means of Capture:
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