Antibody-points Bulletin: CD40 ligand
Antibody-points Bulletin: CD40LG
AKA: IGM, IMD3, TRAP, gp39, CD154, HIGM1, T-BAM, TNFSF5, hCD40L
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Can be cleaved into following 2 chains: CD40 ligand soluble form, and CD40 ligand membrane form.
In early HIV infection, CD40L expression contributes to the immunological control of viral replication by inducing HIV-suppressive chemokines and supporting the production of anti-HIV antibodies and cytotoxic T cells. However, by activating antigen-presenting cells, such as dendritic cells and macrophages, CD40L can also lead to increased CD4+ T cell activation, which promotes the replication of HIV in these lymphocytes.
Protein of Interest in the Following Cases:
Source: Open Targets Platform
Last Known Addresses:
• Cell Membrane
• Cell Surface
Most likely to be found in lymph nodes, tonsils, appendix, bone marrow, and spleen
Source: Human Protein Atlas
B Cell Differentiation
• B Cell Proliferation
• Immunoglobulin Secretion
• Inflammatory Response
• Isotype Switching
• Leukocyte Cell-Cell Adhesion
• Negative Regulation of Apoptotic Process
• Platelet Activation
• Positive Regulation of Endothelial Cell Apoptotic Process
• Positive Regulation of Interleukin-10 Production
• Positive Regulation of Interleukin-12 Production
• Positive Regulation of Interleukin-4 Production
• Positive Regulation of NF-Kappa-b Transcription Factor Activity
• Positive Regulation of T Cell Proliferation
• Regulation of Immune Response
• Regulation of Immunoglobulin Secretion
• T Cell Costimulation
• Tumor Necrosis Factor-Mediated Signaling Pathway
Known Weaknesses: Dapirolizumab Pegolfor systemic lupus erythematosus
Means of Capture:
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