Overview
| Product Name: | GSK3β (Phospho Ser9) Antibody |
| Catalog No: | CUBAB01001 |
| Description: | Rabbit polyclonal antibody GSK3β (Phospho Ser9) antibody. Tested by: WB, IHC, and IF. Reactive for: human, mouse, and rat. |
| Quantity: | 100 μg |
| Species Reactivity: | Human; Mouse; Rat |
| Tested Applications: | WB; IHC; IF |
| Clonality: | Polyclonal |
| Immunogen: | Peptide sequence around phosphorylation site of serine 9 (T-T-S(p)-F-A) derived from Human GSK3β. |
| Source Species: | Rabbit |
Properties
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instructions: | Store at -20°C |
| Concentration: | 1.0 mg/mL |
Recommended Dilutions/Amounts
| WB: | 1/500 - 1/1000 |
| IHC: | 1/50 - 1/100 |
Background
| Background: | The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| Synonym: | H2A/c; H2AFC |
| NCBI Gene ID: | 2932 |
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References
- GSK-3B controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Sun A, et al. Prostate, 2016 Feb. PMID 26440826
- Glycogen synthase kinase-3?? modulation of glucocorticoid responsiveness in COPD. Ngkelo A, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Nov 15. PMID 26320152 Free PMC Article
- [Association between GSK3?? polymorphisms and the smoking habits in young Japanese]. Nagahori K, et al. Nihon Shinkei Seishin Yakurigaku Zasshi, 2015 Jun. PMID 26281299
- The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population. Chen J, et al. J Affect Disord, 2015 Oct 1. PMID 26186530
- Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3?? dependent mechanism. Gavil??n E, et al. Sci Rep, 2015 May 5. PMID 25941117 Free PMC Article
- Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
Stambolic V., Woodgett J.R.
Biochem. J. 303:701-704(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF SER-9. - Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye and Placenta. - Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter.
Lau K.F., Miller C.C.J., Anderton B.H., Shaw P.C.
Genomics 60:121-128(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28. - Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway.
Rhoads A.R., Karkera J.D., Detera-Wadleigh S.D.
Mol. Psychiatry 4:437-442(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-202.
Review