Antibody-points Bulletin: AFAP1

BOLO:

Name: Actin Filament-associated Protein 1

PID: Q8N556

GID: 60312

Nicknames: AFAP

AKA: AFAP110, AFAP-110

Vitals:

   Origins: 4p16.2
   DNA: 181214 bp, NC_000004 (7758713..793992)
   RNA: 7786 bp
   Exons: 20
   Protein: 814 aa, 89.7 kDa

Description:

Be on the lookout for AFAP1: The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.

Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.

Knockdown in MDA-MB-231 cells resulted in loss of actin stress fibers, decreased adhesion and spreading on fibronectin.

Protein of Interest in the Following Cases:

Source: Open Targets Platform

Last Known Addresses:

  •  Actin Cytoskeleton
  •  Cytosol

Known Hangouts:

Source: NCBI

Known Associates:

Source: BioGrid

Gang Associations:

  •  Cytoskeleton Organization
  •  Signal Transduction

Known Weaknesses: None

Reported Sightings:

Source: Pubmed

Means of Capture: