Antibody-points Bulletin: Mucin-20
Jul-11-2017 0 comments Cube Biosystems

Antibody-points Bulletin: Mucin-20

Name: Mucin-20

Mucin-20 has eluded capture and we have no mugshots.

PID: Q8N307

GID: 200958

Nicknames: MUC-20, Muc20

AKA: KIAA1359

Description:

Be on the lookout for Mucin-20. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Protein of Interest in the Following Cases:

Mucin-20 has eluded capture and we have no mugshots.

Source: Open Targets Platform

Last Known Addresses:

  •  Apical cell membrane
  •  Basolateral cell membrane
  •  Microvillus membrane

Known Hangouts:

Mucin-20 has eluded capture and we have no mugshots.

Source: NCBI

Known Associates:

Mucin-20 has eluded capture and we have no mugshots.

Source: BioGrid

Gang Associations:

  •  O-Glycan Processing
  •  Activation Of Mapk Activity
  •  Hepatocyte Growth Factor Receptor Signaling Pathway
  •  Protein Homooligomerization
  •  Stimulatory C-Type Lectin Receptor Signaling Pathway

Known Weaknesses: Not yet determined

Reported Sightings:

Mucin-20 has eluded capture and we have no mugshots.

Source: Pubmed

Means of Capture:

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