Antibody-points Bulletin: MOG

BOLO:

Name: Myelin-oligodendrocyte glycoprotein

PID: Q16653

GID: 4340

Nicknames: MOG

AKA: BTN6, BTNL11, MOGIG2, NRCLP7

Vitals:

   Origins: 6p22.3
   DNA: NG_031873 15392 bp, (5001..20392)
   RNA: NM_005101.3 685 bp
   Exons: 9
   Protein: 247 aa, 18.1 kDa
   Isoforms: 13

Description:

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.By similarity (Microbial infection) Acts as a receptor for rubella virus.

Protein of Interest in the Following Cases:

Source: Open Targets Platform

Last Known Addresses:

  •  Membrane

Known Hangouts:

  •  Brain

    Source: NCBI

Known Associates:

Source: BioGrid

Gang Associations:

  •  Cell adhesion
  •  Central nervous system development
  •  Host-virus interaction

Known Weaknesses: Unknown

Reported Sightings:

Source: Pubmed

Means of Capture: