Antibody-points Bulletin: CD40 ligand

BOLO:

CD40 Ligand

PID: P29965

GID: 959

Nicknames: CD40L

AKA: IGM, IMD3, TRAP, gp39, CD154, HIGM1, T-BAM, TNFSF5, hCD40L

Vitals:

   Origins: Xq26.3
   DNA: NC_000023.11 12214 bp, (136648177..136660390)
   RNA: NM000074.2 3982 bp
   Exons: 5
   Protein: 386 aa, 43.8 kDa

Description:

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.

Can be cleaved into following 2 chains: CD40 ligand soluble form, and CD40 ligand membrane form.

In early HIV infection, CD40L expression contributes to the immunological control of viral replication by inducing HIV-suppressive chemokines and supporting the production of anti-HIV antibodies and cytotoxic T cells. However, by activating antigen-presenting cells, such as dendritic cells and macrophages, CD40L can also lead to increased CD4+ T cell activation, which promotes the replication of HIV in these lymphocytes.

Protein of Interest in the Following Cases:

Source: Open Targets Platform

Last Known Addresses:

  •  Cell Membrane
  •  Cell Surface

Known Hangouts:

Most likely to be found in lymph nodes, tonsils, appendix, bone marrow, and spleen

Source: Human Protein Atlas

Known Associates:

Source: BioGrid

Gang Associations:

B Cell Differentiation
  •   B Cell Proliferation
  •   Immunoglobulin Secretion
  •   Inflammatory Response
  •   Isotype Switching
  •   Leukocyte Cell-Cell Adhesion
  •   Negative Regulation of Apoptotic Process
  •   Platelet Activation
  •   Positive Regulation of Endothelial Cell Apoptotic Process
  •   Positive Regulation of Interleukin-10 Production
  •   Positive Regulation of Interleukin-12 Production
  •   Positive Regulation of Interleukin-4 Production
  •   Positive Regulation of NF-Kappa-b Transcription Factor Activity
  •   Positive Regulation of T Cell Proliferation
  •   Regulation of Immune Response
  •   Regulation of Immunoglobulin Secretion
  •   T Cell Costimulation
  •   Tumor Necrosis Factor-Mediated Signaling Pathway
  •  

Known Weaknesses: Dapirolizumab Pegol

Reported Sightings:

Source: Pubmed

Means of Capture: