Overview
| Product Name: | c-Jun (Phospho Ser73) Antibody |
| Catalog No: | CUBAB01002 |
| Description: | Rabbit polyclonal antibody c-Jun (Phospho Ser73) antibody. Tested by: WB and IHC. Reactive for: human, mouse, and rat. |
| Quantity: | 100 μg |
| Species Reactivity: | Human; Mouse; Rat |
| Tested Applications: | WB; IHC |
| Clonality: | Polyclonal |
| Immunogen: | Peptide sequence around phosphorylation site of serine 73 (L-A-S(p)-P-E) derived from Human c-Jun. |
| Source Species: | Rabbit |
Properties
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instructions: | Store at -20°C |
| Concentration: | 1.0 mg/mL |
Recommended Dilutions/Amounts
| WB: | 1/500 - 1/1000 |
| IHC: | 1/50 - 1/100 |
Background
| Background: | This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] |
| Synonym: | AP1; AP-1; c-Jun |
| NCBI Gene ID: | 3725 |
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References
- AP-1 Transcription Factor Serves as a Molecular Switch between Chlamydia pneumoniae Replication and Persistence. Kr?mer S, et al. Infect Immun, 2015 Jul. PMID 25895972 Free PMC Article
- RNAi-mediated knockdown of the c-jun gene sensitizes radioresistant human nasopharyngeal carcinoma cell line CNE-2R to radiation. Guo SY, et al. Oncol Rep, 2015 Mar. PMID 25571870
- Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer. Zhao C, et al. Cancer Res, 2014 Jul 15. PMID 24830720
- Differentiation-associated genes regulated by c-Jun and decreased in the progression of esophageal squamous cell carcinoma. Luo A, et al. PLoS One, 2014. PMID 24796531 Free PMC Article
- Resveratrol stimulates AP-1-regulated gene transcription. Thiel G, et al. Mol Nutr Food Res, 2014 Jul. PMID 24753227
- Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K., Angel P., le Beau M.M., Karin M.
Proc. Natl. Acad. Sci. U.S.A. 85:9148-9152(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. - Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
Bohmann D., Bos T.J., Admon A., Nishimura T., Vogt P.K., Tjian R.
Science 238:1386-1392(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. - Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. - Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. - NIEHS SNPs program
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Review