Antibody-points Bulletin: RAB7A
Aug-14-2017 0 comments Cube Biosystems

Antibody-points Bulletin: RAB7A

BOLO:

Name: Ras-related Protein Rab-7a 1

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.
Artist Rendering of heterodimer RAB7A (AA:1-207)
Source: Swiss-Model  
CC License

PID: P51149

GID: 7879

Nicknames: RAB7A

AKA: RAB7

Vitals:

   Origins: 3q21.3
   DNA: 88663 bp, NC_000003 (128726136..128814798)
   RNA: 2240 bp
   Exons: 6
   Protein: 207 aa, 23.5 kDa

Description:

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity).

Protein of Interest in the Following Cases:

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.

Source: Open Targets Platform

Last Known Addresses:

  •  Phagosome Membrane
  •  Late Endosome Membrane
  •  Lysosome Membrane
  •  Melanosome Membrane

Known Hangouts:

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.

Source: NCBI

Known Associates:

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.

Source: BioGrid

Gang Associations:

  •  Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class Ii Source
  •  Autophagosome Assembly
  •  Bone Resorption
  •  Early Endosome To Late Endosome Transport
  •  Early Endosome To Late Endosome Transport
  •  Endocytosis
  •  Endosome To Lysosome Transport
  •  Epidermal Growth Factor Catabolic Process
  •  Lipophagy Source:
  •  Membrane Organization
  •  Multi-Organism Intracellular Transport
  •  Negative Regulation Of Exosomal Secretion
  •  Negative Regulation Of Intralumenal Vesicle Formation
  •  Neutrophil Degranulation
  •  Phagosome Acidification
  •  Phagosome-Lysosome Fusion
  •  Phagosome Maturation
  •  Positive Regulation Of Exosomal Secretion
  •  Positive Regulation Of Protein Catabolic Process
  •  Positive Regulation Of Viral Process
  •  Protein Targeting To Lysosome
  •  Protein To Membrane Docking
  •  Protein Transport Source
  •  Retrograde Transport, Endosome To Golgi
  •  Viral Release From Host Cell

Known Weaknesses: None

Reported Sightings:

Be on the lookout for RAB7A: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.

Source: Pubmed

Means of Capture:

 

 

 

 

Tags:
About the author

Related post (12)

Top 20 Gene/Protein Antibodies
Aug-28-2015 / 0 comments / Cube Biosystems

Conducting a literature search of over 3.5 million articles, we compiled a list of some of the most popular potential antibody t..

Top Trending Gene Targets for Antibodies
Sep-14-2015 / 0 comments / Cube Biosystems

Now that whole genome sequence is known, it is interesting to see what genes have captured the research communities attention. A..

Antibody-points Bulletin: Mucin-20
Jul-11-2017 / 0 comments / Cube Biosystems

Mucin-20 is a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tis..

Antibody-points Bulletin: GSK3A
Jul-19-2017 / 0 comments / Cube Biosystems

GSK3A encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins includin..